Abstract：Ten subjects' eyes were exposed to formaldehyde at different doses ((0 mg/m~3,) 1 mg/m~3, 2 mg/m~3, 3 mg/m~3) for five minutes. The content of substance P in the nasal lavage were determined by radio immune assay (RIA). The results showed that the content of substance P increased after exposures, especially during the exposure of 3 mg/m~3 formaldehyde (p<0.05). This maybe explained that formaldehyde could stimulate trigeminal nerve ends of the eyes, which would release substance P from its nasal branches through axon reflex. So we can take the substance P as the molecular biomarker of acute irritation by formaldehyde to investigate the biologic effect of formaldehyde.
收稿日期: 2003-04-25
引用本文:
刘宏亮,童志前,吴江,何胡军,刘军,杨旭. P物质--甲醛急性刺激效应的分子生物标志物[J]. , 2003, 42(4): 0-0.
刘宏亮,童志前,吴江,何胡军,刘军,杨旭. Substance P--the biomarker of acute irritation by formaldehyde. , 2003, 42(4): 0-0.
