Study on naphthalenones from endophytic fungus Fusarium solani B2-1 isolated from Taxus mairei
SHI Yaqun1， LUO Dan1， LI Jia1， TU Xuan1， GUO Zhiyong1， DU Weili2， LUO Xiaogang1,3， DENG Zhangshuang1,2,4
1.Hubei Key Laboratory of Natural Products Research and Development， College of Biological and Pharmaceutical Sciences， China Three Gorges University， Yichang， Hubei 443002；2.Research and Development Center， Angel Yeast Co.， Ltd.， Yichang， Hubei 443003；3.School of Chemical Engineering & Pharmacy， Wuhan Institute of Technology， Wuhan 430073；4.Yichang Key Laboratory of Biocatalysis， College of Biological and Pharmaceutical Sciences， China Three Gorges University， Yichang， Hubei 443002
Abstract：Four naphthalenones (1～4)， including dihydronaphthalenone (1)， 5-hydroxydihydrofusarubin C (2)， Fusarubin (3) and Chrysanthones B (4)， were isolated from an EtOAc extract derived from a solid culture of the endophytic fungal strain Fusarium solani B2-1， which originated from Taxus mairei. Compound 4 was firstly isolated from the fungi of the genus Fusarium. All compounds 1～4 showed weak inhibitory activity against Mycobacterium marinum ATCCBAA-535 with inhibitory rate of 27.6%， 25.0%， 28.4% and 24.4% at a concentration of 10 μg/mL， respectively.
2017, Vol. 51 
