Synthesis and fungicidal activities of 6-aryloxyoxazolo[5,4-d]pyrimidi-7(6H)-ones
ZENG Guoping1， CAI Changquan2， TAN Fen1， DING Mingwu2
1.Hubei Province Key Laboratory of Purification and Application of Plant Anti-cancer Active Ingredients， Hubei University of Education， Wuhan， 430205， China；2.Key Laboratory of Pesticide & Chemical Biology of Ministry of Education，Central China Normal University， Wuhan 430079， China
Abstract：6-Aryloxyoxazolo[5,4-d]pyrimidi-7(6H)-ones 4 were prepared in good overall yields by base catalyzed reaction of various phenols with carbodiimides 2， which were obtained from the aza-Wittig reaction of oxazolyliminophosphorane 1 with isocyanates. Some of 6-aryloxyoxazolo[5,4-d]pyrimidi-7(6H)-ones 4 exhibited good fungicidal activities. For example， compound 4d and 4j showed 92% and 100% inhibitive activity against Botrytis cineapers at 100 μg/mL， superior to the commercial Triadimefon.
2018, Vol. 52 
