Synthesis and preliminary anticancer activity of novel pazopanib derivatives
LIU E1,2， LI Liwei1
1.College of Chemical Engineering and Pharmacy， Jingchu University of Technology， Jingmen， Hubei 448000，China；2.Hubei Key Laboratory of Drug Synthesis and Optimization， Jingchu University of Technology， Jingmen， Hubei 448000， China
Abstract：Based on the structure-activity relationship of pazopanib， four novel pazopanib derivatives were synthesized with 3-methyl-6-nitroindazole as raw materials. The structures of the compounds were identified by 1H NMR， LC-MS and elemental analyses， and the anti-proliferation activity of tumor cells were studied in vitro. MTT method was used to test the inhibition effect of proliferation activity of the target compounds on MGC803 cell. The results showed that the target compounds were able to inhibit the proliferation of MGC803 cells.
2017, Vol. 51 
