Chemical constituents from agarwood “Hong-Tu” and their anti-inflammatory activity
LIU Yuanyuan1， WANG Hao2,3， LI Wei2,3， MEI Wenli2,3， MI Chengneng2,3， WEI Yanmei2,3， DAI Haofu2,3， JIANG Bei1
(1.College of Pharmacy， Dali University， Dali， Yunan 671003， China；2.Hainan Key Laboratory for Research and Development of Natural Products from Li Folk Medicine，Institute of Tropical Bioscience and Biotechnology， Chinese Academy of Tropical Agricultural Sciences， Haikou 570100， China；3.Hainan Engineering Research Center of Agarwood， Haikou 571101， China)
Abstract：Thirteen compounds were isolated from the ethanol extract of agarwood “Hong-Tu” by using various column chromatographic techniques. Their structures were elucidated by spectroscopic data analysis as 7-methoxy-2-[2-(4-methoxyphenyl)ethyl]chromone (1)， 6-methoxy-2-(2-phenylethyl)chromone (2)， 6,7-dimethoxy-2-(2-phenylethyl)chromone (3)， 6-methoxy-2-[2-(4-methoxyphenyl)ethyl]chromone (4)， 6-methoxy-2-[2-(3-methoxyphenyl)ethyl]chromone (5)， 5-hydroxy-6-methoxy-2-[2-(4-methoxyphenyl) ethyl]chromone (6)， 6,8-dihydroxy-2-(2-phenylethyl)chromone (7)，(1β，3α，4aβ，5β，8aα)-4a,5-dimethyl-3-(prop-1-en-2-yl)octahydronaphthalene-1,8a(1H)-diol (8)， rel-(4S,5R,7R,8R,11R)-eremophil-9-en-12,8-olide (9)， cyclodebneyol (10)， methyl crassicid (11)， baimuxinol (12) and 4-epi-15-hydroxyacorenone (13). Compound 1 was a new natural product. All of them were firstly isolated from agarwood “Hong-Tu”. In vitro anti-inflammatory assessment showed that compounds 3， 8 and 13 exhibited anti-inflammatory activities with IC50 values of 81.23 ± 2.83， 39.55 ± 3.75 and 72.63 ± 2.87 μmol·L－1， respectively.
2021, Vol. 55 
