Abstract：DNA interaction properties of ruthenium complexes with terpyridine ligand have been widely reported， while DNA binding activity of metal complexes based on terpyridine analogous ligand， such as bispyridylpyrrole HPDP (PDP-＝2,5-bis(2’-pyridyl)pyrrolide) is seldom reported. In this paper， the DNA interaction properties of known ruthenium complexes [(PDP)Ru(COD)X] (COD＝1,5-cyclooctadiene， X＝Cl－ (1)， NO3(－) (2))， [(PDP)Ru(COD)(H2O)](BF4) (3) and [(PDPCl)Ru(COD)Cl] (HPDPCl＝2,5-bis(2’-pyridyl)-3,4-dichloropyrrolid(4) were studied by the fluorescence， CD and UV-vis spectra. These are different binding mode between 1-4 and ct-DNA. Intercalation and electrostatic binding mode was observed in complex 1 and 4， respectively， and complexes 2 and 3 interacted with ct-DNA probably via a non-classical intercalation. The antitumor activities in vitro of 1-4 against the human ovarian cancer cell line Hela were also evaluated by the MTT assay.
2019, Vol. 53 
