Abstract：The intelligent response polymer micelles have attracted much attention as a carrier of drug controlled release system. Light stimulation is of great interest because of its advantages such as high controllability， clean and high efficiency. In this thesis， 1-pyrenemethyl succinate (PMS) was prepared by the esterification of 1-pyrenemethanol with succinic anhydride， which was grafted onto the carboxymethyl chitosan backbone to obtain photoresponsive polymer (PMS-g-CMCS)， which could self-assemble into light-responsive polymeric micelles in aqueous condition. The size and morphology of the micelles were characterized and their changes before and after light stimulation were studied by dynamic light scattering (DLS) and transmission electron microscopy (TEM). Their photoresponsive mechanism was also investigated by fluorescence and 1H NMR. The results showed that the micelles are spherical-core structures with a diameter of about 200 nm and exhibiteded good storage stability. Under the UV light stimulus， the structure will be able to chang. The photoresponsive mechanism can be attributed to the breakage of ester bond linked to PyM. These properties of micelles show the potential for use as a light controlled release carrier of hydrophobic drug or pesticide.
2017, Vol. 51 
