Simulationanalysis of pyruvate ferredoxin oxidoreductase effect on photosynthetic growth rate of cyanobacteria
MENG Yafei1， SHEN Tie1， PENG Qi1， CHEN Zhen2
1.Key Laboratory of Information of Computing Science of Guizhou Province， Guizhou Normal University， Guiyang 550000， China；2.Academy of Mathematics， Guizhou Normal University， Guiyang 550000， China
Abstract：Photosynthetic organisms convert light energy into biomass energy through photosynthesis， thus storing the energy in their bodies. The rate of biomass energy generation is affected by the photosynthesis growth rate of these organisms. Studying the factors that affect the photosynthetic growth rate is beneficial to promote the rate of biomass energy generation. As the earliest oxygen-evolving photosynthetic microorganism， cyanobacteria have simple genetic background and high carbon sequestration efficiency. Pyruvate ferredoxin oxidoreductase (PFOR) plays a key role in pyruvate metabolism of carbon sequestration process via regulating pyruvate alienation. In this paper， based on the metabolic network of cyanobacteria， the effects of enzyme PFOR on the photosynthetic growth rate of cyanobacteria were estimated. The metabolic network after gene knockout was studied by means of flux equilibrium analysis， flux variability analysis and multi-objective optimization.
2020, Vol. 54 
