Abstract：Foot-and-mouth disease (FMD) is a highly contagious， hot and acute disease caused by foot-and-mouth disease virus (FMDV) in artiodactyls. The large-scale outbreak of FMD will reduce the production of animals and animal related products in the whole country or region， restrict trade， and cause huge economic losses. Persistent infection of FMDV is an important reason for its easy spread and difficult eradication. This review summarizes the existing position in body and infection characteristics of the virus during the persistent infection of FMDV， focusing on the interaction between the virus， host cells and host immune system， which also introduces the research progress of the mechanism of persistent infection， and develops some strategies of preventing and controlling the epidemic， looking forward to providing reference for solving the problem of persistent infection of FMDV.
2022, Vol. 56 
