Abstract：The ISG15 molecule is a ubiquitin-like protein that plays an important role in regulating innate immunity against viral infection. Previous studies have reported the antiviral mechanisms of ISG15 against viral infection， such as influenza virus， hepatitis B virus， HIV virus， Ebola virus， SARS-CoV， MERS-CoV and cytomegalovirus. Recently， a number of studies reported the function of ISG15 in SARS-CoV-2 infection， that ISG15 can be inactivated by the papain-like protease of SARS-CoV-2， thereby inhibiting its antiviral function. In this review， we presented the antiviral mechanism of ISG15， emphasizing the specificity of the antiviral effects of ISG15 against coronaviruses. Moreover， the immune evasion ability of coronavirus via papain-like protease (PLpro) by blocking ISG15-dominated innate immunity， as well as the potential therapeutic inhibitors of PLpro were also reviewed. From the perspective of the molecular mechanism of ISG15's antiviral innate immunity， the latest progress of anti-SARS-CoV-2 drugs was summarized， as well as the prospect of the related drug research and development.
刘欣然,陈 桐,张 煜,陈 红. 泛素样蛋白ISG15抗冠状病毒感染作用的研究进展(英文)[J]. 华中师范大学学报(自然科学版), 2023, 57(5): 748-757.
LIU Xinran,CHEN Tong,ZHANG Yu,CHEN Hong. Progress on the research of anti-infection role of ubiquitin-like protein ISG15 against coronavirus. journal1, 2023, 57(5): 748-757.
2023, Vol. 57 
