Abstract：Alzheimer's Disease (AD) is closely related to the dysregulation of copper (Cu)， and iron (Fe) metabolism. This study conducted a comparative and bioinformatics analysis of transcriptome data from peripheral blood and hippocampal area of AD patients with human Cu and Fe protein groups. Results suggested that the NDUFS2 gene and its corresponding protein in peripheral blood showed significant change and could be used as targets for AD detection. 88 types of Cu and Fe proteins in the hippocampal area are directly correlated with metabolic functions， demethylation， and electron transfer. Furthermore， three core genes (CYCS， CYP3A5， and CYP2D6) and their corresponding Fe proteins could impact the progression of AD by causing cytochrome-related metabolic disorders. This provides a new perspective for understanding and diagnosing AD， revealing the influences of Cu， Fe protein alterations on the course of AD.
2024, Vol. 58 
