Iridoid glycosides from Menyanthes trifoliate L. and their α-glucosidase inhibitory activities
CHEN Jingwen1， LIN Fang1， JIN Guan1，HE Zhiyun1， ZHANG Zhiqi2， LIU Chengxiong1， CHEN Jianfeng1， ZOU Kun1， CHENG Fan1
1.College of Biological and Pharmaceutical Sciences，Key Laboratory of Natural Products Research and Development，China Three Gorges University，Yichang， Hubei 443002， China；2.Shengnongjia National Park Administration， Shengnongjia Forestry District， Hubei， 442400， China
Abstract：To study the chemical constituents of Menyanthes trifoliate L.， solvent extraction method， normal and reverse phase silica gel column chromatography and semi-preparative HPLC were used to isolate the compounds. Their chemical structures were elucidated on the basis of charactermatic physical and chemical properties and spectroscopic analysis. Six iridoid glycoside compounds were isolated from N-butanol extract of the 95% alcohol extract of M. trifoliate.， and they were identified as 7-epiexaltoside (1)， 6″，7″-dihydro-7-epiexaltoside (2)， sweroside (3)， vogeloside (4)， epi-vogeloside (5)， loganin (6). Compounds 2-5 were isolated from this plant for the first time. The results of α-glucosidase inhibitory activity analysis showed certain α-glucosidase inhibitory activities of compound 1-6.
2021, Vol. 55 
