Abstract：The apoptosis rate of Tlymphocyte was analyzed qualitatively by gelatinizing electrophoresis DNA gradient atlas; the ratio between CD~+_4 and CD~+_8 T cells of mice spleen was checked by the flow-typed cell instrument in different time after injecting sonic extractus from treponea denticola; with sonic extractus from treponea denticola catalyzing the two kinds of cells, test the apoptosis rate of CD~+_4 and CD~+_8T cells by the flow-typed cell instrument. The Results shows that: (1) Treponea denticola can induce the mice spleen cells apoptosis; (2) The ratio of CD~+_4/CD~+_8T cells catalyzed by from treponea denticola came to be changeable; (3) With sonic extractus from treponea denticola catalyzing CD~+_4 and CD~+_8T cells of mice spleen in external, the apoptosis rate of CD~+_4T cells obviously increases with the extension of the time; but the apoptosis rate of CD~+_8T cells treaded to become lower, with no change by contracting time. The research of relationship between immuneinhibition of treponem denticola and apoptosis of T cells proves that Treponea denticola has close relation with immunologic decline of the host and the ratio decline between CD~+_4 and CD~+_8T cells, the mechanism of which concerns the components of sonic extractus from treponea denticola that cause the apoptosis of T cells.
收稿日期: 2004-04-25
引用本文:
乔伟民 乔治. 齿密螺旋体免疫抑制现象与T细胞凋亡的关系[J]. , 2004, 43(4): 0-0.
乔伟民 乔治. Studies on relationship between treponem denticola immuneinhibition and apoptosis of T cells in mice. , 2004, 43(4): 0-0.
