Abstract:persons in 39 counties (cities and districts) were investigated for human parasites by adopting the methods of stratification, clustering,random sampling.The general infection rate of human parasites was 52.04 per cent in Hubei Province. It was assured that 65 species of human parasites were in this province, including 16 species of nematodes, 17 species of protozoa, 11 species of trematodes, 5 species of cestodes and 16 species of medical insects. According to materials new available and the documentes information, there were 15 species of parasites rarely or infrequently seen in this province. It was the first time that Dioctophymma renale, Echinochasmus perfoliatus, Opisthorchis felineus, Metagonimus yokogawai, Rhabditis sp., Gongylongema pulchrum and Chilomastix mesnili were reported in Hubei Province. The distribution of human parasites and the prevalence of parasitic infections are related to natural and social ecological factors. These ecological factors involve topography, height above sea level, longitude and latitude, sunshine, atmospheric temperature, precipitation, relative humidity, social economic base, environmental sanitation, as well as age, occupation, cultural level, mode of production and habits and customs of inhabitants.