Abstract：This paper describes the major strategies that have been employed in malaria vaccine development. The pre erythrocytic stage vaccines aim to prevent the development of all clinical symptoms and subsequent malaria transmission. Erythrocytic stage vaccine designed aims to induce antibodies that prevent invasion and infection of erythrocytes, to reduce morbidity and mortality by decreasing the parasite load. Sexual stage 'transmission blocking' vaccines aim to reduce malaria within a community as a whole, but convey no benefit for a malaria infected individual. The design of a malaria vaccine must overcome genetic restriction to be effective to a diverse population. Due to the complex nature of the malaria life cycle, it points out multiple antigens from different stages must also be incorporated into a vaccine.
收稿日期: 2002-01-25
引用本文:
陈思礼,SMOOKER Peter,SPITHILL Terry,杨其仁,陈思祗,陈思义,吴风娇. 疟疾疫苗的研究策略[J]. , 2002, 41(1): 0-0.
陈思礼,SMOOKER Peter,SPITHILL Terry,杨其仁,陈思祗,陈思义,吴风娇. Study on malaria vaccines. , 2002, 41(1): 0-0.
