Abstract：In order to explore the effects of liquid and gaseous formaldehyde on germ cells in male mice, methods SPF-class Kun-Ming male mice were used in experiment, the liquid formaldehyde expose concentration was 0.20, 2.00, 20.00 mg/kg, bw, the agent was i.p. administrated everyday for 7 days. The pathological change was observed and the spermatids weight coefficient and viability, activity, number of sperms and the sperm deformity rate were measured. The gaseous formaldehyde expose level was 0.5 mg/m^3, 1.0 mg/m^3, 3. 0 mg/m^3, the agent was administrated by continuous dynamic inhalation. After first expose for 15 days, the micronuclei rate was measured. The results were. the spermatid pathological damaged, tissue coefficient, viability, activity, number of sperm decreased, and the sperm deformity increased; Gaseous formaldehyde expose could induce the micronuclei of early spermatids. Both expose methods showed a dose-dependent relationship. The conclusion was liquid and gaseous formaldehyde had sperm toxicity in mice.
收稿日期: 2005-03-25
引用本文:
王晓平 段丽菊 严彦 杨旭. 甲醛对雄性小鼠生殖细胞毒作用的研究[J]. , 2005, 44(3): 0-0.
王晓平 段丽菊 严彦 杨旭. Study on formaldehyde''''s effect on germ cells in Male Mice. , 2005, 44(3): 0-0.
