Abstract：To study the effect of stimulus presentation rate on the sound response properties of mouse inferior colliculus(IC) neurons,the tones with duration of 40 ms at characteristic frequency(CF) of recorded neurons were presented to Nembutal anesthetic mice(Mus musculus,Km) at different rates(PR,ranged from 0.5~20 Hz) under free field stimulation conditions.The stimulus intensities were relative to 5 dB above minimum threshold(MT).The post-stimuli-time histograms(PSTHs) of 118 neurons were recorded.The results showed that firing rate of the majority of neurons((87.3%,) 103/118) monotonically decreased with the PR increasing,whereas in a smaller fraction of neurons(12.7%,15/118) it non-monotonically varied.There was significant correlation between the firing rate and the PR(P<0.01).The sound response properties of most recorded neurons could be dramatically influenced by changing the PR even in the low PR range(<3.3 Hz).The total number of neurons with the critical presentation rate(CPR,(<3.3) Hz) and the maximal presentation rate(MPR,< 3.3 Hz) were more than 70%(75.4%,89/118) and 40%(44.9%,53/148),respectively.Moreover,the discharge patterns in part of neurons(17.8%,21/118) were transformed with the PR alteration.Many neurons with tonic responder(T) and phasic-burst responder(PB) were changed into the phasic responder(P).The present data demonstrate that the sound response properties of IC neurons were closely correlated to the PR of acoustic stimulation.
收稿日期: 2005-04-25
引用本文:
吴飞健 刘双喜 陈其才 Bibikov N．G．. 刺激呈现率影响小鼠下丘神经元声反应特性[J]. , 2005, 44(4): 0-0.
吴飞健 刘双喜 陈其才 Bibikov N．G．. Presentation rate of stimulation affected the sound response properties of the mouse inferior colliculus neurons. , 2005, 44(4): 0-0.
