Abstract：Preparation of the gelation submicrospheres by “water in water” has some advantages such as environmental protection. Traditional microspheres preparation methods are expensive and cumbersome， however， microfluidic device is expected to improve the preparation mode of microspheres. In this experiment， gelatin and absolute ethanol were used as experimental raw materials to prepare gelatin submicrospheres by “water in water” through a microfluidic device. The effects of the mass fraction of gelatin submicrospheres， the distance between the first phase needle and the second phase needle， curing mode， measurement time， treatment mode， as well as other factors on the size and monodispersity of the submicrospheres were studied. The result shows when the mass fraction of gelatin solution was 2%， with the distance between the first phase needle and the second phase needle of 7.5 mm， the gelatin submicrospheres was able to generate small size and good monodispersity. The experimental results provided references for preparation of nanospheres by “water in water” with good monodispersity.
2023, Vol. 57 
